Endocrinology medical transcriptions8/19/2023 Journal of Clinical Endocrinology and Metabolism. Visceral adipose tissue indicates the severity of cardiometabolic risk in patients with and without type 2 diabetes: results from the INSPIRE me IAA study. Differential association of visceral adipose tissue with coronary plaque characteristics in patients with and without diabetes mellitus. Proteomic analysis of visceral adipose tissue in pre-obese patients with type 2 diabetes. R., Perez-Martinez P., Escobar-Morreale H. Visceral adipose tissue accumulation and cardiovascular disease risk profile in postmenopausal women with impaired glucose tolerance or type 2 diabetes. Lemieux S., Bédard A., Piché M.-É., Weisnagel S. Hormone Molecular Biology and Clinical Investigation. Visceral adiposopathy: a vascular perspective. Moreover, IL-6 and TP53 as hub genes could serve as biomarkers and therapeutic targets for CVDs.įarb M. The results suggest that regulation of apoptosis in EAT is critical for CVD development. Notably, interleukin-6 (IL-6) and tumor protein p53 (TP53) were the main hub genes in the network. Among the 42 DEGs, genes involved in regulating apoptosis had higher enrichment scores. The included studies reported 42 DEGs identified through comparison of EAT-specific gene expression in patients with and without CVDs. From the 180 papers identified by our initial search strategy, 40 studies met the inclusion criteria and presented DEGs in EAT samples from patients with and without CVDs. The Reporting Recommendations for Tumor Marker Prognostic Studies (PRIMARK) assessment tool was also used for methodological quality assessment. To develop more potential drugs from APC. and reduces lipid levels in the serum and liver by suppressing CREB/CRTC2-mediated both gluconeogenic and SREBP transcriptions. We included original papers that had performed gene expressions in EAT of patients undergoing open-heart surgery. 5 Department of Endocrinology, the First Affiliated Hospital of Harbin Medical University, 150081, Heilongjiang Province. A systematic literature search was conducted in PubMed, SCOPUS, and ISI Web of Science literature databases for papers published before October 2014 that addressed EAT genes and cardiovascular diseases (CVDs). The objective of this study was to perform a systematic review of published literature on differentially expressed genes (DEGs) in human epicardial adipose tissue (EAT) to identify molecules associated with CVDs.
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